Publication: Mammalian oxygen sensing, signalling and gene regulation
Mammalian oxygen sensing, signalling and gene regulation
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Wenger, R. H. (2000). Mammalian oxygen sensing, signalling and gene regulation. Journal of Experimental Biology, 203(Pt. 8), 1253–1263.
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Oxygen is essential to the life of all aerobic organisms. Virtually every cell type is able to sense a limited oxygen supply (hypoxia) and specifically to induce a set of oxygen-regulated genes. This review summarizes current concepts of mammalian oxygen-sensing and signal-transduction pathways. Since the discovery of the hypoxia-inducible factors (HIFs), a great deal of progress has been made in our comprehension of how hypoxia induces the expression of oxygen-regulated genes. The alpha subunit of the heterodimeric transcription fact
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- Wenger, R H
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Wenger, R. H. (2000). Mammalian oxygen sensing, signalling and gene regulation. Journal of Experimental Biology, 203(Pt. 8), 1253–1263.
