Hyperglycaemia but not hyperlipidaemia decreases serum amylase and increases neutrophils in the exocrine pancreas of cats

Zini, Eric; Osto, Melania; Moretti, Simona; Franchini, Marco; Kook, Peter H; Lutz, Hans; Guscetti, Franco; Perren, Aurel; Hoelzle, Ludwig E; Ackermann, Mathias; Lutz, Thomas A; Reusch, Claudia E

doi:10.1016/j.rvsc.2010.01.006

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Zini, E., Osto, M., Moretti, S., Franchini, M., Kook, P. H., Lutz, H., Guscetti, F., Perren, A., Hoelzle, L. E., Ackermann, M., Lutz, T. A., & Reusch, C. E. (2010). Hyperglycaemia but not hyperlipidaemia decreases serum amylase and increases neutrophils in the exocrine pancreas of cats. Research in Veterinary Science, 89(1), 20–26. https://doi.org/10.1016/j.rvsc.2010.01.006

Abstract

The goal of the study was to determine whether hyperglycaemia or hyperlipidaemia causes pancreatitis in cats and to assess the effect of excess serum glucose and lipids on amylase and lipase activity. Ten-day hyperglycaemic and hyperlipidaemic clamps were carried out in five and six healthy cats, respectively. Ten healthy cats received saline and served as controls. The activity of amylase was below the normal range in 4 of 5 hyperglycaemic cats by day 10. The activity of lipase did not vary in any of the cats. Samples of exocrine pan