Publication: Capacity of broadly neutralizing antibodies to inhibit HIV-1 cell-cell transmission is strain- and epitope-dependent
Capacity of broadly neutralizing antibodies to inhibit HIV-1 cell-cell transmission is strain- and epitope-dependent
Date
Date
Date
Citations
Reh, L., Magnus, C., Schanz, M., Weber, J., Uhr, T., Rusert, P., & Trkola, A. (2015). Capacity of broadly neutralizing antibodies to inhibit HIV-1 cell-cell transmission is strain- and epitope-dependent. PLoS Pathogens, 11(7), e1004966. https://doi.org/10.1371/journal.ppat.1004966
Abstract
Abstract
Abstract
An increasing number of broadly neutralizing antibodies (bnAbs) are considered leads for HIV-1 vaccine development and novel therapeutics. Here, we systematically explored the capacity of bnAbs to neutralize HIV-1 prior to and post-CD4 engagement and to block HIV-1 cell-cell transmission. Cell-cell spread is known to promote a highly efficient infection with HIV-1 which can inflict dramatic losses in neutralization potency compared to free virus infection. Selection of bnAbs that are capable of suppressing HIV irrespective of the tran
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Reh, Lucia
- Magnus, Carsten
- Schanz, Merle
- Weber, Jacqueline
- Uhr, Therese
- Rusert, Peter
- Trkola, Alexandra
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Reh, L., Magnus, C., Schanz, M., Weber, J., Uhr, T., Rusert, P., & Trkola, A. (2015). Capacity of broadly neutralizing antibodies to inhibit HIV-1 cell-cell transmission is strain- and epitope-dependent. PLoS Pathogens, 11(7), e1004966. https://doi.org/10.1371/journal.ppat.1004966
