Publication: Metabolic and Lipidomic Assessment of Kidney Cells Exposed to Nephrotoxic Vancomycin Dosages
Metabolic and Lipidomic Assessment of Kidney Cells Exposed to Nephrotoxic Vancomycin Dosages
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Lagies, S., Pichler, R., Vladimirov, G., Gawron, J., Bäzner, F., Schreiner, A., Kadena, D., Plattner, D. A., Lienkamp, S. S., & Kammerer, B. (2021). Metabolic and Lipidomic Assessment of Kidney Cells Exposed to Nephrotoxic Vancomycin Dosages. International Journal of Molecular Sciences, 22(18), 10111. https://doi.org/10.3390/ijms221810111
Abstract
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Abstract
Vancomycin is a glycopeptide antibiotic used against multi-drug resistant gram-positive bacteria such as Staphylococcus aureus (MRSA). Although invaluable against resistant bacteria, vancomycin harbors adverse drug reactions including cytopenia, ototoxicity, as well as nephrotoxicity. Since nephrotoxicity is a rarely occurring side effect, its mechanism is incompletely understood. Only recently, the actual clinically relevant concentration the in kidneys of patients receiving vancomycin was investigated and were found to exceed plasma
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- Lagies, Simon
- Pichler, Roman
- Vladimirov, Georg
- Gawron, Jana
- Bäzner, Fabian
- Schreiner, Annabell
- Kadena, Dajana
- Plattner, Dietmar A
- Lienkamp, Soeren Sten
- Kammerer, Bernd
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Lagies, S., Pichler, R., Vladimirov, G., Gawron, J., Bäzner, F., Schreiner, A., Kadena, D., Plattner, D. A., Lienkamp, S. S., & Kammerer, B. (2021). Metabolic and Lipidomic Assessment of Kidney Cells Exposed to Nephrotoxic Vancomycin Dosages. International Journal of Molecular Sciences, 22(18), 10111. https://doi.org/10.3390/ijms221810111
