Publication: Gene expression noise can promote the fixation of beneficial mutations in fluctuating environments
Gene expression noise can promote the fixation of beneficial mutations in fluctuating environments
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Schmutzer, M., & Wagner, A. (2020). Gene expression noise can promote the fixation of beneficial mutations in fluctuating environments. PLoS Computational Biology, 16(10), e1007727. https://doi.org/10.1101/2020.02.13.947275
Abstract
Abstract
Abstract
Nongenetic phenotypic variation can either speed up or slow down adaptive evolution. We show that it can speed up evolution in environments in which available carbon and energy sources change over time. To this end, we use an experimentally validated model of <jats:italic>Escherichia coli</jats:italic> growth on two alternative carbon sources, glucose and acetate. On the superior carbon source (glucose), all cells achieve high growth rates, while on the inferior carbon source (acetate) only a small fraction of the population manages t
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- Schmutzer, Michael
- Wagner, Andreas
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Schmutzer, M., & Wagner, A. (2020). Gene expression noise can promote the fixation of beneficial mutations in fluctuating environments. PLoS Computational Biology, 16(10), e1007727. https://doi.org/10.1101/2020.02.13.947275
