Publication: Cell fate regulation by chromatin ADP-ribosylation
Cell fate regulation by chromatin ADP-ribosylation
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Abplanalp, J., & Hottiger, M. O. (2017). Cell fate regulation by chromatin ADP-ribosylation. Seminars in Cell & Developmental Biology, 63, 114–122. https://doi.org/10.1016/j.semcdb.2016.09.010
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ADP-ribosylation is an evolutionarily conserved complex posttranslational modification that alters protein function and/or interaction. Intracellularly, it is mainly catalyzed by diphtheria toxin-like ADP-ribosyltransferases (ARTDs), which attach one or several ADP-ribose residues onto target proteins. Several specific mono- and poly-ADP-ribosylation binding modules exist; hydrolases reverse the modification. The best-characterized ARTD family member, ARTD1, regulates various DNA-associated processes. Here, we focus on the role of ART
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- Abplanalp, Jeannette
- Hottiger, Michael O
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Abplanalp, J., & Hottiger, M. O. (2017). Cell fate regulation by chromatin ADP-ribosylation. Seminars in Cell & Developmental Biology, 63, 114–122. https://doi.org/10.1016/j.semcdb.2016.09.010
