Publication: Refined LexA transactivators and their use in combination with the Drosophila Gal4 system
Refined LexA transactivators and their use in combination with the Drosophila Gal4 system
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Yagi, R., Mayer, F., & Basler, K. (2010). Refined LexA transactivators and their use in combination with the Drosophila Gal4 system. Proceedings of the National Academy of Sciences of the United States of America, 107(37), 16166–16171. https://doi.org/10.1073/pnas.1005957107
Abstract
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The use of binary transcriptional systems offers many advantages for experimentally manipulating gene activity, as exemplified by the success of the Gal4/UAS system in Drosophila. To expand the number of applications, a second independent transactivator (TA) is desirable. Here, we present the optimization of an additional system based on LexA and show how it can be applied. We developed a series of LexA TAs, selectively suppressible via Gal80, that exhibit high transcriptional activity and low detrimental effects when expressed in viv
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- Yagi, R
- Mayer, F
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Citations
Yagi, R., Mayer, F., & Basler, K. (2010). Refined LexA transactivators and their use in combination with the Drosophila Gal4 system. Proceedings of the National Academy of Sciences of the United States of America, 107(37), 16166–16171. https://doi.org/10.1073/pnas.1005957107
