Publication: Endotoxin removal by magnetic separation-based blood purification
Endotoxin removal by magnetic separation-based blood purification
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Herrmann, I. K., Urner, M., Graf, S., Schumacher, C. M., Roth-Z’graggen, B., Hasler, M., Stark, W. J., & Beck-Schimmer, B. (2013). Endotoxin removal by magnetic separation-based blood purification. Advanced Healthcare Materials, 2(6), 829–835. https://doi.org/10.1002/adhm.201200358
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This work describes a magnetic separation-based approach using polymyxin B-functionalized metal alloy nanomagnets for the rapid elimination of endotoxins from human blood in vitro and functional assays to evaluate the biological relevance of the blood purification process. Playing a central role in gram-negative sepsis, bacteria-derived endotoxins are attractive therapeutic targets. However, both direct endotoxin detection in and removal from protein-rich fluids remains challenging. We present the synthesis and functionalization of ul
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- Herrmann, Inge K
- Urner, Martin
- Graf, Samuel
- Schumacher, Christoph M
- Roth-Z'graggen, Birgit
- Hasler, Melanie
- Stark, Wendelin J
- Beck-Schimmer, Beatrice
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Herrmann, I. K., Urner, M., Graf, S., Schumacher, C. M., Roth-Z’graggen, B., Hasler, M., Stark, W. J., & Beck-Schimmer, B. (2013). Endotoxin removal by magnetic separation-based blood purification. Advanced Healthcare Materials, 2(6), 829–835. https://doi.org/10.1002/adhm.201200358
