Publication: CD8+ T cells retain protective functions despite sustained inhibitory receptor expression during Epstein-Barr virus infection in vivo
CD8+ T cells retain protective functions despite sustained inhibitory receptor expression during Epstein-Barr virus infection in vivo
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Chatterjee, B., Deng, Y., Holler, A., Núñez, N. G., Azzi, T., Vanoaica, L. D., Müller, A., Zdimerova, H., Antsiferova, O., Zbinden, A., Capaul, R., Dreyer, J. H., Nadal, D., Becher, B., Robinson, M. D., Stauss, H., & Münz, C. (2019). CD8+ T cells retain protective functions despite sustained inhibitory receptor expression during Epstein-Barr virus infection in vivo. PLoS Pathogens, 15, e1007748. https://doi.org/10.1371/journal.ppat.1007748
Abstract
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Abstract
Epstein Barr virus (EBV) is one of the most ubiquitous human pathogens in the world, persistently infecting more than 90% of the adult human population. It drives some of the strongest human CD8+ T cell responses, which can be observed during symptomatic primary infection known as infectious mononucleosis (IM). Despite high viral loads and prolonged CD8+ T cell stimulation during IM, EBV enters latency and is under lifelong immune control in most individuals that experience this disease. We investigated whether changes in T cell funct
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Creators (Authors)
- Chatterjee, Bithi
- Deng, Yun
- Holler, Angelika
- Núñez, Nicolás Gonzalo
- Azzi, Tarik
- Vanoaica, Liliana Danusia
- Müller, Anne
- Zdimerova, Hana
- Antsiferova, Olga
- Zbinden, Andrea
- Capaul, Riccarda
- Dreyer, Johannes H
- Nadal, David
- Becher, Burkhard
- Stauss, Hans
- Münz, Christian
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Chatterjee, B., Deng, Y., Holler, A., Núñez, N. G., Azzi, T., Vanoaica, L. D., Müller, A., Zdimerova, H., Antsiferova, O., Zbinden, A., Capaul, R., Dreyer, J. H., Nadal, D., Becher, B., Robinson, M. D., Stauss, H., & Münz, C. (2019). CD8+ T cells retain protective functions despite sustained inhibitory receptor expression during Epstein-Barr virus infection in vivo. PLoS Pathogens, 15, e1007748. https://doi.org/10.1371/journal.ppat.1007748
