Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial

Spahn, Donat R; Schoenrath, Felix; Spahn, Gabriela H; Seifert, Burkhardt; Stein, Philipp; Theusinger, Oliver M; Kaserer, Alexander; Hegemann, Inga; Hofmann, Axel; Maisano, Francesco; Falk, Volkmar

doi:10.1016/S0140-6736(18)32555-8

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Spahn, D. R., Schoenrath, F., Spahn, G. H., Seifert, B., Stein, P., Theusinger, O. M., Kaserer, A., Hegemann, I., Hofmann, A., Maisano, F., & Falk, V. (2019). Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial. The Lancet, 393, 2201–2212. https://doi.org/10.1016/S0140-6736(18)32555-8

Abstract

BACKGROUND Anaemia and iron deficiency are frequent in patients scheduled for cardiac surgery. This study assessed whether immediate preoperative treatment could result in reduced perioperative red blood cell (RBC) transfusions and improved outcome. METHODS In this single-centre, randomised, double-blind, parallel-group controlled study, patients undergoing elective cardiac surgery with anaemia (n=253; haemoglobin concentration (Hb) <120 g/L in women and Hb <130 g/L in men) or isolated iron deficiency (n=252; ferritin <100 mcg/L, no a