Publication: Herpes simplex virus co-infection facilitates rolling circle replication of the adeno-associated virus genome
Herpes simplex virus co-infection facilitates rolling circle replication of the adeno-associated virus genome
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Meier, A. F., Tobler, K., Leisi, R., Lkharrazi, A., Ros, C., & Fraefel, C. (2021). Herpes simplex virus co-infection facilitates rolling circle replication of the adeno-associated virus genome. PLoS Pathogens, 17(6), e1009638. https://doi.org/10.1371/journal.ppat.1009638
Abstract
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Abstract
Adeno-associated virus (AAV) genome replication only occurs in the presence of a co-infecting helper virus such as adenovirus type 5 (AdV5) or herpes simplex virus type 1 (HSV-1). AdV5-supported replication of the AAV genome has been described to occur in a strand-displacement rolling hairpin replication (RHR) mechanism initiated at the AAV 3’ inverted terminal repeat (ITR) end. It has been assumed that the same mechanism applies to HSV-1-supported AAV genome replication. Using Southern analysis and nanopore sequencing as a novel, hig
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- Tobler, Kurt
- Leisi, Remo
- Lkharrazi, Anouk
- Ros, Carlos
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Meier, A. F., Tobler, K., Leisi, R., Lkharrazi, A., Ros, C., & Fraefel, C. (2021). Herpes simplex virus co-infection facilitates rolling circle replication of the adeno-associated virus genome. PLoS Pathogens, 17(6), e1009638. https://doi.org/10.1371/journal.ppat.1009638
