Publication: Analysis of serum glycome by lectin microarrays for prostate cancer patients - a search for aberrant glycoforms
Analysis of serum glycome by lectin microarrays for prostate cancer patients - a search for aberrant glycoforms
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Bertok, T., Jane, E., Chrenekova, N., Hroncekova, S., Bertokova, A., Hires, M., Vikartovska, A., Kubanikova, P., Sokol, R., Fillo, J., Kasak, P., Borsig, L., & Tkac, J. (2020). Analysis of serum glycome by lectin microarrays for prostate cancer patients - a search for aberrant glycoforms. Glycoconjugate Journal, 37(6), 703–711. https://doi.org/10.1007/s10719-020-09958-4
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This is the first work focused on glycoprofiling of whole N- and O- glycome using lectins in an array format applied for analysis of serum samples from healthy individuals, benign prostate hyperplasia (BPH) patients, and prostate cancer (PCa) patients. Lectin microarray was prepared using traditional lectins with the incorporation of 2 recombinant bacterial lectins and 3 human lectins (17 lectins in total). Clinical validation of glycans as biomarkers was done in two studies: discrimination of healthy individuals with BPH patients vs.
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- Bertok, Tomas
- Jane, Eduard
- Chrenekova, Nikola
- Hroncekova, Stefania
- Bertokova, Aniko
- Hires, Michal
- Vikartovska, Alica
- Kubanikova, Petra
- Sokol, Roman
- Fillo, Juraj
- Kasak, Peter
- Borsig, Lubor
- Tkac, Jan
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Bertok, T., Jane, E., Chrenekova, N., Hroncekova, S., Bertokova, A., Hires, M., Vikartovska, A., Kubanikova, P., Sokol, R., Fillo, J., Kasak, P., Borsig, L., & Tkac, J. (2020). Analysis of serum glycome by lectin microarrays for prostate cancer patients - a search for aberrant glycoforms. Glycoconjugate Journal, 37(6), 703–711. https://doi.org/10.1007/s10719-020-09958-4
