Publication: The Amide Local Anesthetic Ropivacaine Attenuates Acute Rejection After Allogeneic Mouse Lung Transplantation
The Amide Local Anesthetic Ropivacaine Attenuates Acute Rejection After Allogeneic Mouse Lung Transplantation
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Maeyashiki, T., Jang, J.-H., Janker, F., Yamada, Y., Inci, I., Weder, W., Piegeler, T., & Jungraithmayr, W. (2019). The Amide Local Anesthetic Ropivacaine Attenuates Acute Rejection After Allogeneic Mouse Lung Transplantation. Lung, 197(2), 217–226. https://doi.org/10.1007/s00408-019-00197-5
Abstract
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PURPOSE
Acute allograft rejection after lung transplantation remains an unsolved hurdle. The pathogenesis includes an inflammatory response during and after transplantation. Ropivacaine, an amide-linked local anesthetic, has been shown to attenuate lung injury due to its anti-inflammatory effects. We hypothesized that the drug would also be able to attenuate acute rejection (AR) after allogeneic lung transplantation.
METHODS
Allogeneic, orthotopic, single left lung transplantation was performed between BALB/c (donors) and C57BL/6 (
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Creators (Authors)
- Maeyashiki, Tatsuo
- Jang, Jae-Hwi
- Janker, Florian
- Yamada, Yoshito
- Inci, Ilhan
- Weder, Walter
- Piegeler, Tobias
- Jungraithmayr, Wolfgang
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Citations
Maeyashiki, T., Jang, J.-H., Janker, F., Yamada, Y., Inci, I., Weder, W., Piegeler, T., & Jungraithmayr, W. (2019). The Amide Local Anesthetic Ropivacaine Attenuates Acute Rejection After Allogeneic Mouse Lung Transplantation. Lung, 197(2), 217–226. https://doi.org/10.1007/s00408-019-00197-5
