In vitro norepinephrine significantly activates isolated platelets from healthy volunteers and critically ill patients following severe traumatic brain injury

Tschuor, Christoph; Asmis, Lars M; Lenzlinger, Philipp M; Tanner, Martina; Härter, Luc; Keel, Marius; Stocker, Reto; Stover, J F

doi:10.1186/cc6931

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Tschuor, C., Asmis, L. M., Lenzlinger, P. M., Tanner, M., Härter, L., Keel, M., Stocker, R., & Stover, J. F. (2008). In vitro norepinephrine significantly activates isolated platelets from healthy volunteers and critically ill patients following severe traumatic brain injury. Critical Care, 12, R80. https://doi.org/10.1186/cc6931

Abstract

INTRODUCTION: Norepinephrine, regularly used to increase systemic arterial blood pressure and thus improve cerebral perfusion following severe traumatic brain injury (TBI), may activate platelets. This, in turn, could promote microthrombosis formation and induce additional brain damage. METHODS: The objective of this study was to investigate the influence of norepinephrine on platelets isolated from healthy volunteers and TBI patients during the first two post-traumatic weeks. A total of 18 female and 18 male healthy volunteers of dif