Publication: Macrophage depletion diminishes implant-wear-induced inflammatory osteolysis in a mouse model
Macrophage depletion diminishes implant-wear-induced inflammatory osteolysis in a mouse model
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Ren, W., Markel, D. C., Schwendener, R., Ding, Y., Wu, B., & Wooley, P. H. (2008). Macrophage depletion diminishes implant-wear-induced inflammatory osteolysis in a mouse model. Journal of Biomedical Materials Research Part A, 85(4), 1043–1051. https://doi.org/10.1002/jbm.a.31665
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The purpose of this study was to determine whether macrophage depletion using clodronate liposomes diminishes wear-debris-induced inflammatory osteolysis in a murine osteolysis model. Ultra high molecular weight polyethylene (UHMWPE) particles were introduced into established air pouches on BALB/c mice, followed by implantation of calvaria bone from syngeneic littermates. Macrophages were depleted by the intraperitoneal injection of clodronate liposome (2 mg) 2 days before bone implantation and re-injection every 3 days (1 mg) until t
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- Ren, W
- Markel, D C
- Schwendener, R
- Ding, Y
- Wu, B
- Wooley, P H
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Ren, W., Markel, D. C., Schwendener, R., Ding, Y., Wu, B., & Wooley, P. H. (2008). Macrophage depletion diminishes implant-wear-induced inflammatory osteolysis in a mouse model. Journal of Biomedical Materials Research Part A, 85(4), 1043–1051. https://doi.org/10.1002/jbm.a.31665
