Publication: A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation
A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation
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Kaufman, C. K., Mosimann, C., Fan, Z. P., Yang, S., Thomas, A. J., Ablain, J., Tan, J. L., Fogley, R. D., van Rooijen, E., Hagedorn, E. J., Ciarlo, C., White, R. M., Matos, D. A., Puller, A.-C., Santoriello, C., Liao, E. C., Young, R. A., & Zon, L. I. (2016). A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science, 351(6272), aad2197. https://doi.org/10.1126/science.aad2197
Abstract
Abstract
Abstract
The “cancerized field” concept posits that cancer-prone cells in a given tissue share an oncogenic mutation, but only discreet clones within the field initiate tumors. Most benign nevi carry oncogenic BRAFV600E mutations but rarely become melanoma.The zebrafish crestin gene is expressed embryonically in neural crest progenitors (NCPs) and specifically reexpressed in melanoma. Live imaging of transgenic zebrafish crestin reporters shows that within a cancerized field (BRAFV600E-mutant; p53-deficient), a single melanocyte reactivates th
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Creators (Authors)
- Kaufman, C K
- Mosimann, C
- Fan, Z P
- Yang, S
- Thomas, A J
- Ablain, J
- Tan, J L
- Fogley, R D
- van Rooijen, E
- Hagedorn, E J
- Ciarlo, C
- White, R M
- Matos, D A
- Puller, A-C
- Santoriello, C
- Liao, E C
- Young, R A
- Zon, L I
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Citations
Kaufman, C. K., Mosimann, C., Fan, Z. P., Yang, S., Thomas, A. J., Ablain, J., Tan, J. L., Fogley, R. D., van Rooijen, E., Hagedorn, E. J., Ciarlo, C., White, R. M., Matos, D. A., Puller, A.-C., Santoriello, C., Liao, E. C., Young, R. A., & Zon, L. I. (2016). A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science, 351(6272), aad2197. https://doi.org/10.1126/science.aad2197
