Publication: Tacrolimus depresses local immune cell infiltration but fails to reduce cortical contusion volume in brain-injured rats
Tacrolimus depresses local immune cell infiltration but fails to reduce cortical contusion volume in brain-injured rats
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Thomale, U. W., Bender, M., Casalis, P., Rupprecht, S., Griebenow, M., Neumann, K., Woiciechowsky, C., Unterberg, A. W., & Stover, J. F. (2007). Tacrolimus depresses local immune cell infiltration but fails to reduce cortical contusion volume in brain-injured rats. Immunobiology, 212(7), 567–576. https://doi.org/10.1016/j.imbio.2007.01.007
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The immunosuppressant drug tacrolimus (FK-506) failed to show an anti-edematous effect despite suppressing pro-inflammatory cytokines in cerebrospinal fluid following focal traumatic brain injury. By questioning the role of the inflammatory response as a pharmacological target, we investigated the effects of FK-506 on immune cell infiltration in brain-injured rats. Following induction of a cortical contusion, male Sprague-Dawley rats received FK-506 or physiological saline intraperitoneally. Brains were removed at 24 h, 72 h or 7 days
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- Thomale, U W
- Bender, M
- Casalis, P
- Rupprecht, S
- Griebenow, M
- Neumann, K
- Woiciechowsky, C
- Unterberg, A W
- Stover, J F
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Thomale, U. W., Bender, M., Casalis, P., Rupprecht, S., Griebenow, M., Neumann, K., Woiciechowsky, C., Unterberg, A. W., & Stover, J. F. (2007). Tacrolimus depresses local immune cell infiltration but fails to reduce cortical contusion volume in brain-injured rats. Immunobiology, 212(7), 567–576. https://doi.org/10.1016/j.imbio.2007.01.007
