Publication: Visualization of individual cell division history in complex tissues using iCOUNT
Visualization of individual cell division history in complex tissues using iCOUNT
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Denoth-Lippuner, A., Jaeger, B. N., Liang, T., Royall, L. N., Chie, S. E., Buthey, K., Machado, D., Korobeynyk, V. I., Kruse, M., Munz, C. M., Gerbaulet, A., Simons, B. D., & Jessberger, S. (2021). Visualization of individual cell division history in complex tissues using iCOUNT. Cell Stem Cell, 28(11), 2020-2034.e12. https://doi.org/10.1016/j.stem.2021.08.012
Abstract
Abstract
Abstract
The division potential of individual stem cells and the molecular consequences of successive rounds of proliferation remain largely unknown. Here, we developed an inducible cell division counter (iCOUNT) that reports cell division events in human and mouse tissues in vitro and in vivo. Analyzing cell division histories of neural stem/progenitor cells (NSPCs) in the developing and adult brain, we show that iCOUNT can provide novel insights into stem cell behavior. Further, we use single-cell RNA sequencing (scRNA-seq) of iCOUNT-labeled
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- Denoth-Lippuner, Annina
- Jaeger, Baptiste N
- Liang, Tong
- Royall, Lars N
- Chie, Stefanie E
- Buthey, Kilian
- Machado, Diana
- Korobeynyk, Vladislav I
- Kruse, Merit
- Munz, Clara M
- Gerbaulet, Alexander
- Simons, Benjamin D
- Jessberger, Sebastian
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Denoth-Lippuner, A., Jaeger, B. N., Liang, T., Royall, L. N., Chie, S. E., Buthey, K., Machado, D., Korobeynyk, V. I., Kruse, M., Munz, C. M., Gerbaulet, A., Simons, B. D., & Jessberger, S. (2021). Visualization of individual cell division history in complex tissues using iCOUNT. Cell Stem Cell, 28(11), 2020-2034.e12. https://doi.org/10.1016/j.stem.2021.08.012
