Publication: Prostaglandin-mediated effects in early canine corpus luteum: In vivo effects on vascular and immune factors
Prostaglandin-mediated effects in early canine corpus luteum: In vivo effects on vascular and immune factors
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Tavares Pereira, M., Gram, A., Nowaczyk, R., Boos, A., Hoffmann, B., Janowski, T., & Kowalewski, M. P. (2019). Prostaglandin-mediated effects in early canine corpus luteum: In vivo effects on vascular and immune factors. Reproductive Biology, 19(1), 100–111. https://doi.org/10.1016/j.repbio.2019.02.001
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Prostaglandins (PGs) are important regulators of the early corpus luteum (CL) in the dog. Whereas, initially, CL is gonadotropin independent, in the second half of its lifespan, hypophyseal support is required. The transition period is marked by decreased availability of PGs, in particular of PGE2. We previously reported that inhibition of COX2/PTGS2 in vivo suppressed luteal production of PGE2, lowered circulating progesterone and negatively affected luteal development. Therefore, bitches were treated with a COX2-specific blocker, fi
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Tavares Pereira, M., Gram, A., Nowaczyk, R., Boos, A., Hoffmann, B., Janowski, T., & Kowalewski, M. P. (2019). Prostaglandin-mediated effects in early canine corpus luteum: In vivo effects on vascular and immune factors. Reproductive Biology, 19(1), 100–111. https://doi.org/10.1016/j.repbio.2019.02.001