Publication: Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis.
Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis.
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Egli, D., Selvaraj, A., Yepiskoposyan, H., Zhang, B., Hafen, E., Georgiev, O., & Schaffner, W. (2003). Knockout of “metal-responsive transcription factor” MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis. The EMBO Journal, 22(1), 100–108. https://doi.org/10.1093/emboj/cdg012
Abstract
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Abstract
'Metal-responsive transcription factor-1' (MTF-1), a zinc finger protein, is conserved from mammals to insects. In the mouse, it activates metallothionein genes and other target genes in response to several cell stress conditions, notably heavy metal load. The knockout of MTF-1 in the mouse has an embryonic lethal phenotype accompanied by liver degeneration. Here we describe the targeted disruption of the MTF-1 gene in Drosophila by homologous recombination. Unlike the situation in the mouse, knockout of MTF-1 in Drosophila is not let
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Creators (Authors)
- Egli, D
- Selvaraj, A
- Yepiskoposyan, H
- Zhang, B
- Hafen, E
- Georgiev, Oleg
- Schaffner, Walter
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Egli, D., Selvaraj, A., Yepiskoposyan, H., Zhang, B., Hafen, E., Georgiev, O., & Schaffner, W. (2003). Knockout of “metal-responsive transcription factor” MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis. The EMBO Journal, 22(1), 100–108. https://doi.org/10.1093/emboj/cdg012
