Publication: The transcription factor HIF-1α in NKp46+ ILCs limits chronic intestinal inflammation and fibrosis
The transcription factor HIF-1α in NKp46+ ILCs limits chronic intestinal inflammation and fibrosis
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Nelius, E., Fan, Z., Sobecki, M., Krzywinska, E., Nagarajan, S., Ferapontova, I., Gotthardt, D., Takeda, N., Sexl, V., & Stockmann, C. (2024). The transcription factor HIF-1α in NKp46+ ILCs limits chronic intestinal inflammation and fibrosis. Life Science Alliance, 7(9), e202402593. https://doi.org/10.26508/lsa.202402593
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Innate lymphoid cells (ILCs) are critical for intestinal adaptation to microenvironmental challenges, and the gut mucosa is characterized by low oxygen. Adaptation to low oxygen is mediated by hypoxia-inducible transcription factors (HIFs), and the HIF-1α subunit shapes an ILC phenotype upon acute colitis that contributes to intestinal damage. However, the impact of HIF signaling in NKp46$^{+}$
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- Nelius, Eric
- Fan, Zheng
- Sobecki, Michal
- Krzywinska, Ewelina
- Nagarajan, Shunmugam
- Ferapontova, Irina
- Gotthardt, Dagmar
- Takeda, Norihiko
- Sexl, Veronika
- Stockmann, Christian
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Nelius, E., Fan, Z., Sobecki, M., Krzywinska, E., Nagarajan, S., Ferapontova, I., Gotthardt, D., Takeda, N., Sexl, V., & Stockmann, C. (2024). The transcription factor HIF-1α in NKp46+ ILCs limits chronic intestinal inflammation and fibrosis. Life Science Alliance, 7(9), e202402593. https://doi.org/10.26508/lsa.202402593
