Publication: Posttranscriptional Regulation of the Human LDL Receptor by the U2-Spliceosome
Posttranscriptional Regulation of the Human LDL Receptor by the U2-Spliceosome
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Zanoni, P., Panteloglou, G., Othman, A., Haas, J. T., Meier, R., Rimbert, A., Futema, M., Abou-Khalil, Y., Nørrelykke, S. F., Rzepiela, A. J., Stoma, S., Stebler, M., van Dijk, F., Wijers, M., Wolters, J. C., Dalila, N., Huijkman, N. C. A., Smit, M., Gallo, A., … von Eckardstein, A. (2022). Posttranscriptional Regulation of the Human LDL Receptor by the U2-Spliceosome. Circulation Research, 130, 80–95. https://doi.org/10.1161/CIRCRESAHA.120.318141
Abstract
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Background: The low-density lipoprotein receptor (LDLR) in the liver is the major determinant of LDL-cholesterol levels in human plasma. The discovery of genes that regulate the activity of LDLR helps to identify pathomechanisms of hypercholesterolemia and novel therapeutic targets against atherosclerotic cardiovascular disease.
Methods: We performed a genome-wide RNA interference screen for genes limiting the uptake of fluorescent LDL into Huh-7 hepatocarcinoma cells. Top hit genes were validated by in vitro experiments as well as
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Creators (Authors)
- Zanoni, Paolo
- Panteloglou, Grigorios
- Othman, Alaa
- Haas, Joel T
- Meier, Roger
- Rimbert, Antoine
- Futema, Marta
- Abou-Khalil, Yara
- Nørrelykke, Simon Flyvbjerg
- Rzepiela, Andrzej J
- Stoma, Szymon
- Stebler, Michael
- van Dijk, Freerk
- Wijers, Melinde
- Wolters, Justina C
- Dalila, Nawar
- Huijkman, Nicolette C A
- Smit, Marieke
- Gallo, Antonio
- Carreau, Valerie
- Philippi, Anne
- Rabès, Jean-Pierre
- Boileau, Catherine
- Visentin, Michele
- Vonghia, Luisa
- Weyler, Jonas
- Francque, Sven
- Verrijken, An
- Verhaegen, Ann
- Van Gaal, Luc
- von Eckardstein, Arnold
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Citations
Zanoni, P., Panteloglou, G., Othman, A., Haas, J. T., Meier, R., Rimbert, A., Futema, M., Abou-Khalil, Y., Nørrelykke, S. F., Rzepiela, A. J., Stoma, S., Stebler, M., van Dijk, F., Wijers, M., Wolters, J. C., Dalila, N., Huijkman, N. C. A., Smit, M., Gallo, A., … von Eckardstein, A. (2022). Posttranscriptional Regulation of the Human LDL Receptor by the U2-Spliceosome. Circulation Research, 130, 80–95. https://doi.org/10.1161/CIRCRESAHA.120.318141
