Publication: TCF/LEF dependent and independent transcriptional regulation of Wnt/β-catenin target genes
TCF/LEF dependent and independent transcriptional regulation of Wnt/β-catenin target genes
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Doumpas, N., Lampart, F., Robinson, M. D., Lentini, A., Nestor, C. E., Cantù, C., & Basler, K. (2019). TCF/LEF dependent and independent transcriptional regulation of Wnt/β-catenin target genes. The EMBO Journal, 38, e98873. https://doi.org/10.15252/embj.201798873
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Abstract
During canonical Wnt signalling, the activity of nuclear β-catenin is largely mediated by the TCF/LEF family of transcription factors. To challenge this view, we used the CRISPR/Cas9 genome editing approach to generate HEK 293T cell clones lacking all four TCF/LEF genes. By performing unbiased whole transcriptome sequencing analysis, we found that a subset of β-catenin transcriptional targets did not require TCF/LEF factors for their regulation. Consistent with this finding, we observed in a genome-wide analysis that β-catenin occupie
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- Doumpas, Nikolaos
- Lampart, Franziska
- Lentini, Antonio
- Nestor, Colm E
- Cantù, Claudio
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Doumpas, N., Lampart, F., Robinson, M. D., Lentini, A., Nestor, C. E., Cantù, C., & Basler, K. (2019). TCF/LEF dependent and independent transcriptional regulation of Wnt/β-catenin target genes. The EMBO Journal, 38, e98873. https://doi.org/10.15252/embj.201798873
