Publication: Vaccination-based immunotherapy to target profibrotic cells in liver and lung
Vaccination-based immunotherapy to target profibrotic cells in liver and lung
Date
Date
Date
Citations
Sobecki, M., Chen, J. M., Krzywinska, E., Nagarajan, S., Fan, Z., Nelius, E., Monné Rodríguez, J. M., Seehusen, F., Hussein, A., Moschini, G., Hajam, E. Y., Kiran, R., Gotthardt, D., Debbache, J., Badoual, C., Sato, T., Isagawa, T., Takeda, N., Tanchot, C., … Seehusen, F. (2022). Vaccination-based immunotherapy to target profibrotic cells in liver and lung. Cell Stem Cell, 29(10), 1459-1474.e9. https://doi.org/10.1016/j.stem.2022.08.012
Abstract
Abstract
Abstract
Fibrosis is the final path of nearly every form of chronic disease, regardless of the pathogenesis. Upon chronic injury, activated, fibrogenic fibroblasts deposit excess extracellular matrix, and severe tissue fibrosis can occur in virtually any organ. However, antifibrotic therapies that target fibrogenic cells, while sparing homeostatic fibroblasts in healthy tissues, are limited. We tested whether specific immunization against endogenous proteins, strongly expressed in fibrogenic cells but highly restricted in quiescent fibroblasts
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Page end
Page end
Page end
Item Type
Item Type
Item Type
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Sobecki, M., Chen, J. M., Krzywinska, E., Nagarajan, S., Fan, Z., Nelius, E., Monné Rodríguez, J. M., Seehusen, F., Hussein, A., Moschini, G., Hajam, E. Y., Kiran, R., Gotthardt, D., Debbache, J., Badoual, C., Sato, T., Isagawa, T., Takeda, N., Tanchot, C., … Seehusen, F. (2022). Vaccination-based immunotherapy to target profibrotic cells in liver and lung. Cell Stem Cell, 29(10), 1459-1474.e9. https://doi.org/10.1016/j.stem.2022.08.012
