Publication: Cellular and Molecular Principles of Neurogenic Aging in the Mouse Dentate Gyrus
Cellular and Molecular Principles of Neurogenic Aging in the Mouse Dentate Gyrus
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Wu, Y. (2024). Cellular and Molecular Principles of Neurogenic Aging in the Mouse Dentate Gyrus. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-258678
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Neural stem cells (NSCs) in the hippocampal dentate gyrus (DG) generate new neurons throughout life that are relevant to the functions of learning and emotional response. The ability of NSCs to proliferate and to give rise to new neurons strongly decreases with advancing age, contributing to the susceptibility of cognitive impairments in the aged brain. In the thesis, I first used in vivo two-photon (2P) laser scanning microscopy and showed that impaired neurogenesis in the aged brain is caused by the combinatorial effects of increase
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Wu, Y. (2024). Cellular and Molecular Principles of Neurogenic Aging in the Mouse Dentate Gyrus. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-258678
