Publication: Synthetic circuits reveal how mechanisms of gene regulatory networks constrain evolution
Synthetic circuits reveal how mechanisms of gene regulatory networks constrain evolution
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Date
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Schaerli, Y., Jiménez, A., Duarte, J. M., Mihajlovic, L., Renggli, J., Isalan, M., Sharpe, J., & Wagner, A. (2018). Synthetic circuits reveal how mechanisms of gene regulatory networks constrain evolution. Molecular Systems Biology, 14(9), e8102. https://doi.org/10.15252/msb.20178102
Abstract
Abstract
Abstract
Phenotypic variation is the raw material of adaptive Darwinian evolution. The phenotypic variation found in organismal development is biased towards certain phenotypes, but the molecular mechanisms behind such biases are still poorly understood. Gene regulatory networks have been proposed as one cause of constrained phenotypic variation. However, most pertinent evidence is theoretical rather than experimental. Here, we study evolutionary biases in two synthetic gene regulatory circuits expressed in Escherichia coli that produce a gene
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Creators (Authors)
- Schaerli, Yolanda
- Jiménez, Alba
- Duarte, José M
- Mihajlovic, Ljiljana
- Renggli, Julien
- Isalan, Mark
- Sharpe, James
- Wagner, Andreas
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Citations
Schaerli, Y., Jiménez, A., Duarte, J. M., Mihajlovic, L., Renggli, J., Isalan, M., Sharpe, J., & Wagner, A. (2018). Synthetic circuits reveal how mechanisms of gene regulatory networks constrain evolution. Molecular Systems Biology, 14(9), e8102. https://doi.org/10.15252/msb.20178102
