Publication: Association of liver injury from specific drugs, or groups of drugs, with polymorphisms in HLA and other genes in a genome-wide association study
Association of liver injury from specific drugs, or groups of drugs, with polymorphisms in HLA and other genes in a genome-wide association study
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Nicoletti, P., Aithal, G. P., Bjornsson, E. S., Andrade, R. J., Sawle, A., Arrese, M., Barnhart, H. X., Bondon-Guitton, E., Hayashi, P. H., Bessone, F., Carvajal, A., Cascorbi, I., Cirulli, E. T., Chalasani, N., Conforti, A., Coulthard, S. A., Daly, M. J., Day, C. P., Dillon, J. F., … et al. (2017). Association of liver injury from specific drugs, or groups of drugs, with polymorphisms in HLA and other genes in a genome-wide association study. Gastroenterology, 152(5), 1078–1089. https://doi.org/10.1053/j.gastro.2016.12.016
Abstract
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BACKGROUND & AIMS: We performed a genome-wide association study (GWAS) to identify genetic risk factors for drug-induced liver injury (DILI) from licensed drugs without previously reported genetic risk factors. METHODS: We performed a GWAS of 862 persons with DILI and 10,588 population-matched controls. The first set of cases was recruited before May 2009 in Europe (n = 137) and the United States (n = 274). The second set of cases were identified from May 2009 through May 2013 from international collaborative studies performed in Euro
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- Nicoletti, Paola
- Aithal, Guruprasad P
- Bjornsson, Einar S
- Andrade, Raul J
- Sawle, Ashley
- Arrese, Marco
- Barnhart, Huiman X
- Bondon-Guitton, Emmanuelle
- Hayashi, Paul H
- Bessone, Fernando
- Carvajal, Alfonso
- Cascorbi, Ingolf
- Cirulli, Elizabeth T
- Chalasani, Naga
- Conforti, Anita
- Coulthard, Sally A
- Daly, Mark J
- Day, Christopher P
- Dillon, John F
- Fontana, Robert J
- Grove, Jane I
- Hallberg, Pär
- Hernández, Nelia
- Ibáñez, Luisa
- Kullak-Ublick, Gerd A
- Laitinen, Tarja
- Larrey, Dominique
- Lucena, M Isabel
- Maitland-van der Zee, Anke H
- Martin, Jennifer H
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Nicoletti, P., Aithal, G. P., Bjornsson, E. S., Andrade, R. J., Sawle, A., Arrese, M., Barnhart, H. X., Bondon-Guitton, E., Hayashi, P. H., Bessone, F., Carvajal, A., Cascorbi, I., Cirulli, E. T., Chalasani, N., Conforti, A., Coulthard, S. A., Daly, M. J., Day, C. P., Dillon, J. F., … et al. (2017). Association of liver injury from specific drugs, or groups of drugs, with polymorphisms in HLA and other genes in a genome-wide association study. Gastroenterology, 152(5), 1078–1089. https://doi.org/10.1053/j.gastro.2016.12.016
