Publication: Expanded CAG/CTG repeats resist gene silencing mediated by targeted epigenome editing
Expanded CAG/CTG repeats resist gene silencing mediated by targeted epigenome editing
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Yang, B., Borgeaud, A. C., Buřičová, M., Aeschbach, L., Rodríguez-Lima, O., Ruiz Buendía, G. A., Cinesi, C., Taylor, A. S., Baubec, T., & Dion, V. (2022). Expanded CAG/CTG repeats resist gene silencing mediated by targeted epigenome editing. Human Molecular Genetics, 31(3), 386–398. https://doi.org/10.1093/hmg/ddab255
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Expanded CAG/CTG repeat disorders affect over 1 in 2500 individuals worldwide. Potential therapeutic avenues include gene silencing and modulation of repeat instability. However, there are major mechanistic gaps in our understanding of these processes, which prevent the rational design of an efficient treatment. To address this, we developed a novel system, ParB/ANCHOR-mediated Inducible Targeting (PInT), in which any protein can be recruited at will to a GFP reporter containing an expanded CAG/CTG repeat. Previous studies have implic
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Yang, B., Borgeaud, A. C., Buřičová, M., Aeschbach, L., Rodríguez-Lima, O., Ruiz Buendía, G. A., Cinesi, C., Taylor, A. S., Baubec, T., & Dion, V. (2022). Expanded CAG/CTG repeats resist gene silencing mediated by targeted epigenome editing. Human Molecular Genetics, 31(3), 386–398. https://doi.org/10.1093/hmg/ddab255
