Publication: A phospho-deficient α3 glycine receptor mutation alters synaptic glycine and GABA release in mouse spinal dorsal horn neurons
A phospho-deficient α3 glycine receptor mutation alters synaptic glycine and GABA release in mouse spinal dorsal horn neurons
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Werynska, K., Neumann, E., Cramer, T., Ganley, R. P., Gingras, J., & Zeilhofer, H. U. (2023). A phospho-deficient α3 glycine receptor mutation alters synaptic glycine and GABA release in mouse spinal dorsal horn neurons. Journal of Physiology, 601, 4121–4133. https://doi.org/10.1113/JP284589
Abstract
Abstract
Abstract
Glycine receptors (GlyRs), together with GABA$_{A}$ receptors, mediate postsynaptic inhibition in most spinal cord and hindbrain neurons. In several CNS regions, GlyRs are also expressed in presynaptic terminals. Here, we analysed the effects of a phospho-deficient mutation (S346A) in GlyR α3 subunits on inhibitory synaptic transmission in superficial spinal dorsal horn neurons, where this subunit is abundantly expressed. Unexpectedly, we found that not only were the amplitudes of evoked glycinergic inhibitory postsynaptic currents (I
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- Werynska, Karolina
- Neumann, Elena
- Cramer, Teresa
- Ganley, Robert P
- Gingras, Jacinthe
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Citations
Werynska, K., Neumann, E., Cramer, T., Ganley, R. P., Gingras, J., & Zeilhofer, H. U. (2023). A phospho-deficient α3 glycine receptor mutation alters synaptic glycine and GABA release in mouse spinal dorsal horn neurons. Journal of Physiology, 601, 4121–4133. https://doi.org/10.1113/JP284589
