Publication: How organic anions accumulate in hepatocytes lacking mrp2: evidence in rat liver
How organic anions accumulate in hepatocytes lacking mrp2: evidence in rat liver
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Millet, P., Moulin, M., Stieger, B., Daali, Y., & Pastor, C. M. (2011). How organic anions accumulate in hepatocytes lacking mrp2: evidence in rat liver. Journal of Pharmacology and Experimental Therapeutics, 336(3), 624–632. https://doi.org/10.1124/jpet.110.175406
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In the liver, the accumulation of hepatobiliary contrast agents is a crucial issue to understand the images of liver scintigraphy or magnetic resonance (MR) imaging. Thus, depending on the regulation of uptake and exit membrane systems in normal and injured hepatocytes, these contrast agents will accumulate differently within cells. Gadobenate dimeglumine (Gd-BOPTA) is a hepatobiliary MR contrast agent that distributes to the extracellular space and enters into rat hepatocytes through the sinusoidal transporters, organic anion-transpo
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Millet, P., Moulin, M., Stieger, B., Daali, Y., & Pastor, C. M. (2011). How organic anions accumulate in hepatocytes lacking mrp2: evidence in rat liver. Journal of Pharmacology and Experimental Therapeutics, 336(3), 624–632. https://doi.org/10.1124/jpet.110.175406