Publication: Polygenic risk scores across the extended psychosis spectrum
Polygenic risk scores across the extended psychosis spectrum
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Smigielski, L., Papiol, S., Theodoridou, A., Heekeren, K., Gerstenberg, M., Wotruba, D., Buechler, R., Hoffmann, P., Herms, S., Adorjan, K., Anderson-Schmidt, H., Budde, M., Comes, A. L., Gade, K., Heilbronner, M., Heilbronner, U., Kalman, J. L., Klöhn-Saghatolislam, F., Reich-Erkelenz, D., … Grünblatt, E. (2021). Polygenic risk scores across the extended psychosis spectrum. Translational Psychiatry, 11, 600. https://doi.org/10.1038/s41398-021-01720-0
Abstract
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Abstract
As early detection of symptoms in the subclinical to clinical psychosis spectrum may improve health outcomes, knowing the probabilistic susceptibility of developing a disorder could guide mitigation measures and clinical intervention. In this context, polygenic risk scores (PRSs) quantifying the additive effects of multiple common genetic variants hold the potential to predict complex diseases and index severity gradients. PRSs for schizophrenia (SZ) and bipolar disorder (BD) were computed using Bayesian regression and continuous shri
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Creators (Authors)
- Smigielski, Lukasz
- Papiol, Sergi
- Heekeren, Karsten
- Gerstenberg, Miriam
- Wotruba, Diana
- Buechler, Roman
- Hoffmann, Per
- Herms, Stefan
- Adorjan, Kristina
- Anderson-Schmidt, Heike
- Budde, Monika
- Comes, Ashley L
- Gade, Katrin
- Heilbronner, Maria
- Heilbronner, Urs
- Kalman, Janos L
- Klöhn-Saghatolislam, Farahnaz
- Reich-Erkelenz, Daniela
- Schaupp, Sabrina K
- Schulte, Eva C
- Senner, Fanny
- Anghelescu, Ion-George
- Arolt, Volker
- Baune, Bernhard T
- Dannlowski, Udo
- Dietrich, Detlef E
- Fallgatter, Andreas J
- Figge, Christian
- Jäger, Markus
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Smigielski, L., Papiol, S., Theodoridou, A., Heekeren, K., Gerstenberg, M., Wotruba, D., Buechler, R., Hoffmann, P., Herms, S., Adorjan, K., Anderson-Schmidt, H., Budde, M., Comes, A. L., Gade, K., Heilbronner, M., Heilbronner, U., Kalman, J. L., Klöhn-Saghatolislam, F., Reich-Erkelenz, D., … Grünblatt, E. (2021). Polygenic risk scores across the extended psychosis spectrum. Translational Psychiatry, 11, 600. https://doi.org/10.1038/s41398-021-01720-0
