Publication: Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
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de Rojas, I., Moreno-Grau, S., Tesi, N., Grenier-Boley, B., et al, Clark, C., Grünblatt, E., & Popp, J. (2021). Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores. Nature Communications, 12, 3417. https://doi.org/10.1038/s41467-021-22491-8
Abstract
Abstract
Abstract
Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants
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Creators (Authors)
- de Rojas, Itziar
- Moreno-Grau, Sonia
- Tesi, Niccolo
- Grenier-Boley, Benjamin
- Clark, Christopher
- Popp, Julius
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de Rojas, I., Moreno-Grau, S., Tesi, N., Grenier-Boley, B., et al, Clark, C., Grünblatt, E., & Popp, J. (2021). Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores. Nature Communications, 12, 3417. https://doi.org/10.1038/s41467-021-22491-8
