The Vault Complex Is Significantly Involved in Therapeutic Responsiveness of Endocrine Tumors and Linked to Autophagy under Chemotherapeutic Conditions

Bornstein, Stefan; Shapiro, Igor; Mazumdar, Alekhya; Zitzmann, Kathrin; Nölting, Svenja; Luca, Edlira; Beuschlein, Felix; Sharma, Ashish; Hantel, Constanze

doi:10.5167/uzh-255579

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Bornstein, S., Shapiro, I., Mazumdar, A., Zitzmann, K., Nölting, S., Luca, E., Beuschlein, F., Sharma, A., & Hantel, C. (2023). The Vault Complex Is Significantly Involved in Therapeutic Responsiveness of Endocrine Tumors and Linked to Autophagy under Chemotherapeutic Conditions. Cancers, 15, 1783. https://doi.org/10.3390/cancers15061783

Abstract

Cancers display dynamic interactions with their complex microenvironments that influence tumor growth, invasiveness, and immune evasion, thereby also influencing potential resistance to therapeutic treatments. The tumor microenvironment (TME) includes cells of the immune system, the extracellular matrix, blood vessels, and other cell types, such as fibroblasts or adipocytes. Various cell types forming this TME secrete exosomes, and molecules thereby released into the TME have been shown to be important mediators of cellular communicat