Publication: European Society of Toxicologic Pathology (Pathology 2.0 Molecular Pathology Special Interest Group): Review of In Situ Hybridization Techniques for Drug Research and Development
European Society of Toxicologic Pathology (Pathology 2.0 Molecular Pathology Special Interest Group): Review of In Situ Hybridization Techniques for Drug Research and Development
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Monné Rodríguez, J. M., Frisk, A.-L., Kreutzer, R., Lemarchand, T., Lezmi, S., Saravanan, C., Stierstorfer, B., Thuilliez, C., Vezzali, E., Wieczorek, G., Yun, S.-W., & Schaudien, D. (2023). European Society of Toxicologic Pathology (Pathology 2.0 Molecular Pathology Special Interest Group): Review of In Situ Hybridization Techniques for Drug Research and Development. Toxicologic Pathology, 51, 92–111. https://doi.org/10.1177/01926233231178282
Abstract
Abstract
Abstract
In situ hybridization (ISH) is used for the localization of specific nucleic acid sequences in cells or tissues by complementary binding of a nucleotide probe to a specific target nucleic acid sequence. In the last years, the specificity and sensitivity of ISH assays were improved by innovative techniques like synthetic nucleic acids and tandem oligonucleotide probes combined with signal amplification methods like branched DNA, hybridization chain reaction and tyramide signal amplification. These improvements increased the application
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Creators (Authors)
- Monné Rodríguez, Josep M
- Frisk, Anna-Lena
- Kreutzer, Robert
- Lemarchand, Thomas
- Lezmi, Stephane
- Saravanan, Chandrassegar
- Stierstorfer, Birgit
- Thuilliez, Céline
- Vezzali, Enrico
- Wieczorek, Grazyna
- Yun, Seong-Wook
- Schaudien, Dirk
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Monné Rodríguez, J. M., Frisk, A.-L., Kreutzer, R., Lemarchand, T., Lezmi, S., Saravanan, C., Stierstorfer, B., Thuilliez, C., Vezzali, E., Wieczorek, G., Yun, S.-W., & Schaudien, D. (2023). European Society of Toxicologic Pathology (Pathology 2.0 Molecular Pathology Special Interest Group): Review of In Situ Hybridization Techniques for Drug Research and Development. Toxicologic Pathology, 51, 92–111. https://doi.org/10.1177/01926233231178282
