Publication: Two-step activation prodrugs: transplatin mediated binding of chemotherapeutic agents to vitamin B-12
Two-step activation prodrugs: transplatin mediated binding of chemotherapeutic agents to vitamin B-12
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Tran, M. T. Q., Furger, E., & Alberto, R. (2013). Two-step activation prodrugs: transplatin mediated binding of chemotherapeutic agents to vitamin B-12. Organic & Biomolecular Chemistry, 11(19), 3247–3254. https://doi.org/10.1039/C3OB40093J
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Clinically approved organic chemotherapeutic drugs such as cytarabine, dacarbazine and anastrozole were attached to B12via a {CN-trans-Pt(NH3)2}-bridge to yield {Co}-CN-{trans-Pt(NH3)2}-{drug}. The active organic drugs are protected by the platinum complex and by B12, which represents at the same time the targeting vector. We refer to these bioconjugates as two-step activation prodrugs since two reactions are finally required to liberate the actual organic drugs. All three prodrugs are soluble and stable in water. The physiologi
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- Tran, Mai Thanh Quynh
- Furger, Evelyne
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Tran, M. T. Q., Furger, E., & Alberto, R. (2013). Two-step activation prodrugs: transplatin mediated binding of chemotherapeutic agents to vitamin B-12. Organic & Biomolecular Chemistry, 11(19), 3247–3254. https://doi.org/10.1039/C3OB40093J