Publication: Efficacy of anti-PD-1 and ipilimumab alone or in combination in acral melanoma
Efficacy of anti-PD-1 and ipilimumab alone or in combination in acral melanoma
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Bhave, P., Ahmed, T., Lo, S. N., Shoushtari, A., Zaremba, A., Versluis, J. M., Mangana, J., Weichenthal, M., Si, L., Lesimple, T., Robert, C., Trojanello, C., Wicky, A., Heywood, R., Tran, L., Batty, K., Dimitriou, F., Stansfeld, A., Allayous, C., … et al. (2022). Efficacy of anti-PD-1 and ipilimumab alone or in combination in acral melanoma. Journal for ImmunoTherapy of Cancer, 10, e004668. https://doi.org/10.1136/jitc-2022-004668
Abstract
Abstract
Abstract
BackgroundAcral melanoma is a rare melanoma subtype with poor prognosis. Importantly, these patients were not identified as a specific subgroup in the landmark melanoma trials involving ipilimumab and the anti-programmed cell death protein-1 (PD-1) agents nivolumab and pembrolizumab. There is therefore an absence of prospective clinical trial evidence regarding the efficacy of checkpoint inhibitors (CPIs) in this population. Acral melanoma has lower tumor mutation burden (TMB) than other cutaneous sites, and primary site is associated
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Creators (Authors)
- Bhave, Prachi
- Ahmed, Tasnia
- Lo, Serigne N
- Shoushtari, Alexander
- Zaremba, Anne
- Versluis, Judith M
- Mangana, Joanna
- Weichenthal, Michael
- Si, Lu
- Lesimple, Thierry
- Robert, Caroline
- Trojanello, Claudia
- Wicky, Alexandre
- Heywood, Richard
- Tran, Lena
- Batty, Kathleen
- Dimitriou, Florentia
- Stansfeld, Anna
- Allayous, Clara
- Schwarze, Julia K
- Mooradian, Meghan J
- Klein, Oliver
- Mehmi, Inderjit
- Roberts-Thomson, Rachel
- Maurichi, Andrea
- Yeoh, Hui-Ling
- Khattak, Adnan
- Zimmer, Lisa
- Blank, Christian U
- Ramelyte, Egle
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Citations
Bhave, P., Ahmed, T., Lo, S. N., Shoushtari, A., Zaremba, A., Versluis, J. M., Mangana, J., Weichenthal, M., Si, L., Lesimple, T., Robert, C., Trojanello, C., Wicky, A., Heywood, R., Tran, L., Batty, K., Dimitriou, F., Stansfeld, A., Allayous, C., … et al. (2022). Efficacy of anti-PD-1 and ipilimumab alone or in combination in acral melanoma. Journal for ImmunoTherapy of Cancer, 10, e004668. https://doi.org/10.1136/jitc-2022-004668
