Publication: PIRCHE-II scores prove useful as a predictive biomarker among kidney transplant recipients with rejection: An analysis of indication and follow-up biopsies
PIRCHE-II scores prove useful as a predictive biomarker among kidney transplant recipients with rejection: An analysis of indication and follow-up biopsies
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Spitznagel, T., Matter, L. S., Kaufmann, Y. L., Nilsson, J., von Moos, S., & Schachtner, T. (2022). PIRCHE-II scores prove useful as a predictive biomarker among kidney transplant recipients with rejection: An analysis of indication and follow-up biopsies. Frontiers in Immunology, 13, 949933. https://doi.org/10.3389/fimmu.2022.949933
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BackgroundIndication biopsies for deterioration of kidney allograft function often require follow-up biopsies to assess treatment response or lack of improvement. Immune-mediated injury, namely borderline rejection (BLR), T-cell mediated rejection (TCMR), or antibody-mediated rejection (ABMR), results from preformed or de novo alloreactivity due to donor and recipient HLA-mismatches. The impact of HLA-mismatches on alloreactivity is determined by highly immunogenic HLA-epitopes.MethodsWe analyzed 123 kidney transplant recipients (KTRs
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- Spitznagel, Tahm
- Matter, Laurenz S
- Kaufmann, Yves L
- Nilsson, Jakob
- von Moos, Seraina
- Schachtner, Thomas
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Spitznagel, T., Matter, L. S., Kaufmann, Y. L., Nilsson, J., von Moos, S., & Schachtner, T. (2022). PIRCHE-II scores prove useful as a predictive biomarker among kidney transplant recipients with rejection: An analysis of indication and follow-up biopsies. Frontiers in Immunology, 13, 949933. https://doi.org/10.3389/fimmu.2022.949933
