The impact of methylphenidate and its enantiomers on dopamine synthesis and metabolism in vitro

Bartl, Jasmin; Palazzesi, Ferruccio; Parrinello, Michele; Hommers, Leif; Riederer, Peter; Walitza, Susanne; Grünblatt, Edna

doi:10.1016/j.pnpbp.2017.07.002

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Bartl, J., Palazzesi, F., Parrinello, M., Hommers, L., Riederer, P., Walitza, S., & Grünblatt, E. (2017). The impact of methylphenidate and its enantiomers on dopamine synthesis and metabolism in vitro. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 79(Pt B), 281–288. https://doi.org/10.1016/j.pnpbp.2017.07.002

Abstract

Methylphenidate (MPH), a psychostimulant, is an effective first-line treatment for the symptoms associated with Attention-Deficit/Hyperactivity Disorder (ADHD). Although most MPH formulations are composed of the racemic 1:1 mixture of the two enantiomers (d- and l-threo), converging lines of evidence indicate that d-threo MPH seems to be superior to the l-isomer. We aimed to investigate whether MPH racemic mixture or pure enantiomers influence the enzyme activity of tyrosine hydroxylase (TH), monoamine oxidase B (MAO-B), catechol-O-me