Paracrine Adenoviral Delivery of Therapeutic Payloads for Cancer Therapy

Abstract

Adenoviral vectors are the most commonly used delivery vectors for clinical gene therapy due to their favorable characteristics: (i) they do not integrate into the host cell genome and thus harbor a reduced risk of insertional mutagenesis, (ii) they efficiently transduce dividing and non-dividing cells, and (iii) they have a large packaging capacity allowing large and/or multiple cargo delivery. However, site-specific gene delivery in vivo is still compromised because of the endogenous adenoviral tropism and interactions with the host Show more