Publication: Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries
Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries
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Moritz, C., Berardi, F., Abate, C., & Peri, F. (2015). Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries. Neuroscience Letters, 591, 13–18. https://doi.org/10.1016/j.neulet.2015.02.004
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Microglial cells are responsible for clearing and maintaining the central nervous system (CNS) microenvironment. Upon brain damage, they move toward injuries to clear the area by engulfing dying neurons. However, in the context of many neurological disorders chronic microglial responses are responsible for neurodegeneration. Therefore, it is important to understand how these cells can be “switched-off” and regain their ramified state. Current research suggests that microglial inflammatory responses can be inhibited by sigma (σ) recept
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Moritz, C., Berardi, F., Abate, C., & Peri, F. (2015). Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries. Neuroscience Letters, 591, 13–18. https://doi.org/10.1016/j.neulet.2015.02.004