Publication: Assessment of Favipiravir and Remdesivir in Combination for SARS-CoV-2 Infection in Syrian Golden Hamsters
Assessment of Favipiravir and Remdesivir in Combination for SARS-CoV-2 Infection in Syrian Golden Hamsters
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Neary, M., Gallardo-Toledo, E., Sharp, J., Herriott, J., Kijak, E., Bramwell, C., Cox, H., Tatham, L., Box, H., Curley, P., Arshad, U., Rajoli, R. K. R., Pertinez, H., Valentijn, A., Pennington, S. H., Caygill, C. H., Lopeman, R. C., Biagini, G. A., Kipar, A., … Owen, A. (2024). Assessment of Favipiravir and Remdesivir in Combination for SARS-CoV-2 Infection in Syrian Golden Hamsters. Viruses, 16(12), 1838. https://doi.org/10.3390/v16121838
Abstract
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Abstract
Favipiravir (FVP) and remdesivir (RDV) have demonstrable antiviral activity against SARS-CoV-2. Here, the efficacy of FVP, RDV, and FVP with RDV (FVP + RDV) in combination was assessed in Syrian golden hamsters challenged with SARS-CoV- 2 (B.1.1.7) following intraperitoneal administration. At day 4 post infection, viral RNA and viral antigen expression were significantly lower in lungs for all three treatment groups compared to the sham treatment. Similarly, viral titres in the lungs were lower in all treatment groups compared to the
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Creators (Authors)
- Neary, Megan
- Gallardo-Toledo, Eduardo
- Sharp, Joanne
- Herriott, Joanne
- Kijak, Edyta
- Bramwell, Chloe
- Cox, Helen
- Tatham, Lee
- Box, Helen
- Curley, Paul
- Arshad, Usman
- Rajoli, Rajith K R
- Pertinez, Henry
- Valentijn, Anthony
- Pennington, Shaun H
- Caygill, Claire H
- Lopeman, Rose C
- Biagini, Giancarlo A
- Kipar, Anja
- Stewart, James P
- Owen, Andrew
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Neary, M., Gallardo-Toledo, E., Sharp, J., Herriott, J., Kijak, E., Bramwell, C., Cox, H., Tatham, L., Box, H., Curley, P., Arshad, U., Rajoli, R. K. R., Pertinez, H., Valentijn, A., Pennington, S. H., Caygill, C. H., Lopeman, R. C., Biagini, G. A., Kipar, A., … Owen, A. (2024). Assessment of Favipiravir and Remdesivir in Combination for SARS-CoV-2 Infection in Syrian Golden Hamsters. Viruses, 16(12), 1838. https://doi.org/10.3390/v16121838
