Publication: Syntheses and biological investigations of kirkamide and oseltamivir hybrid derivatives
Syntheses and biological investigations of kirkamide and oseltamivir hybrid derivatives
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Sieber, S., Hsiao, C.-C., Emmanouilidou, D., Debowski, A. W., Stubbs, K. A., & Gademann, K. (2020). Syntheses and biological investigations of kirkamide and oseltamivir hybrid derivatives. Tetrahedron, 76(51), 131386. https://doi.org/10.1016/j.tet.2020.131386
Abstract
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The C7N-aminocyclitol kirkamide was recently isolated from the plant obligate symbiont Candidatus Burkholderia kirkii and was hypothesized to be beneficial to the plant host due to its cytotoxic activity against insects and arthropods. To study its mechanism of action and inspired by its structural similarity with N-acetylglucosamine (GlcNAc) and oseltamivir, kirkamide-oseltamivir hybrid derivatives were synthesized and investigated for their biological activity. Interestingly, kirkamide analogues were reasonably potent against a know
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- Hsiao, Chien-Chi
- Emmanouilidou, Despina
- Debowski, Aleksandra W
- Stubbs, Keith A
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Sieber, S., Hsiao, C.-C., Emmanouilidou, D., Debowski, A. W., Stubbs, K. A., & Gademann, K. (2020). Syntheses and biological investigations of kirkamide and oseltamivir hybrid derivatives. Tetrahedron, 76(51), 131386. https://doi.org/10.1016/j.tet.2020.131386
