Publication: A distinct hypothalamus–habenula circuit governs risk preference
A distinct hypothalamus–habenula circuit governs risk preference
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Groos, D., Reuss, A. M., Rupprecht, P., Stachniak, T., Lewis, C., Han, S., Roggenbach, A., Sturman, O., Sych, Y., Wieckhorst, M., Bohacek, J., Karayannis, T., Aguzzi, A., & Helmchen, F. (2025). A distinct hypothalamus–habenula circuit governs risk preference. Nature Neuroscience, 28(2), 361–373. https://doi.org/10.1038/s41593-024-01856-4
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Appropriate risk evaluation is essential for survival in complex, uncertain environments. Confronted with choosing between certain (safe) and uncertain (risky) options, animals show strong preference for either option consistently across extended time periods. How such risk preference is encoded in the brain remains elusive. A candidate region is the lateral habenula (LHb), which is prominently involved in value-guided behavior. Here, using a balanced two-alternative choice task and longitudinal two-photon calcium imaging in mice, we
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Groos, D., Reuss, A. M., Rupprecht, P., Stachniak, T., Lewis, C., Han, S., Roggenbach, A., Sturman, O., Sych, Y., Wieckhorst, M., Bohacek, J., Karayannis, T., Aguzzi, A., & Helmchen, F. (2025). A distinct hypothalamus–habenula circuit governs risk preference. Nature Neuroscience, 28(2), 361–373. https://doi.org/10.1038/s41593-024-01856-4
