Influence of metal ions on human lymphocytes and the generation of titanium-specific T-lymphocytes

Chan, E; Cadosch, D; Gautschi, O P; Sprengel, K; Filgueira, L

doi:10.5301/JABB.2011.8567

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Chan, E., Cadosch, D., Gautschi, O. P., Sprengel, K., & Filgueira, L. (2011). Influence of metal ions on human lymphocytes and the generation of titanium-specific T-lymphocytes. Journal of Applied Biomaterials & Biomechanics, 9(2), 137–143. https://doi.org/10.5301/JABB.2011.8567

Abstract

Background: There is mounting evidence to suggest the involvement of the immune system by means of activation by metal ions released via biocorrosion, in the pathophysiologic mechanisms of aseptic loosening of orthopedic implants. However, the detailed mechanisms of how metal ions become antigenic and are presented to T-lymphocytes, in addition to how the local inflammatory response is driven, remain to be investigated. Methods: Human T-lymphocytes were cultured in the presence of a variety of metal ions before investigating functiona