Publication: Loss of the Notch effector RBPJ promotes tumorigenesis
Loss of the Notch effector RBPJ promotes tumorigenesis
Date
Date
Date
Citations
Kulic, I., et al, & Robinson, M. D. (2015). Loss of the Notch effector RBPJ promotes tumorigenesis. Journal of Experimental Medicine, 212(1), 37–52. https://doi.org/10.1084/jem.20121192
Abstract
Abstract
Abstract
Aberrant Notch activity is oncogenic in several malignancies, but it is unclear how expression or function of downstream elements in the Notch pathway affects tumor growth. Transcriptional regulation by Notch is dependent on interaction with the DNA-binding transcriptional repressor, RBPJ, and consequent derepression or activation of associated gene promoters. We show here that RBPJ is frequently depleted in human tumors. Depletion of RBPJ in human cancer cell lines xenografted into immunodeficient mice resulted in activation of canon
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Kulic, Iva
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Page end
Page end
Page end
Item Type
Item Type
Item Type
In collections
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Kulic, I., et al, & Robinson, M. D. (2015). Loss of the Notch effector RBPJ promotes tumorigenesis. Journal of Experimental Medicine, 212(1), 37–52. https://doi.org/10.1084/jem.20121192
