Publication: Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging
Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging
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Altmeyer, M., & Hottiger, M. O. (2009). Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging. Aging, 1(5), 458–469. https://doi.org/10.18632/aging.100052
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Poly(ADP-ribose) polymerase 1 (PARP1) is a chromatin-associated nuclear protein, which functions as molecular stress sensor. Reactive oxygen species, responsible for the most plausible and currently acceptable global mechanism to explain the aging process, strongly activate the enzymatic activity of PARP1 and the formation of poly(ADP-ribose) (PAR) from NAD(+). Consumption of NAD(+) links PARP1 to energy metabolism and to a large number of NAD(+)-dependent enzymes, such as the sirtuins. As transcriptional cofactor for NF-kappaB-depend
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- Altmeyer, M
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Altmeyer, M., & Hottiger, M. O. (2009). Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging. Aging, 1(5), 458–469. https://doi.org/10.18632/aging.100052
