Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium

Kong, Xiang-Zhen; Boedhoe, Premika S W; Abe, Yoshinari; Alonso, Pino; Ameis, Stephanie H; Arnold, Paul D; Assogna, Francesca; Baker, Justin T; Batistuzzo, Marcelo C; Benedetti, Francesco; Beucke, Jan C; Bollettini, Irene; Bose, Anushree; Brem, Silvia; Brennan, Brian P; Buitelaar, Jan; Calvo, Rosa; Cheng, Yuqi; Cho, Kang Ik K; Dallaspezia, Sara

doi:10.1016/j.biopsych.2019.04.022

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Kong, X.-Z., Boedhoe, P. S. W., Abe, Y., Alonso, P., Ameis, S. H., Arnold, P. D., Assogna, F., Baker, J. T., Batistuzzo, M. C., Benedetti, F., Beucke, J. C., Bollettini, I., Bose, A., Brem, S., Brennan, B. P., Buitelaar, J., Calvo, R., Cheng, Y., Cho, K. I. K., … et al. (2020). Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium. Biological Psychiatry, 87(12), 1022–1034. https://doi.org/10.1016/j.biopsych.2019.04.022

Abstract

BACKGROUND

Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. METHODS

We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhanci