A mutation in the silver gene leads to defects in melanosome biogenesis and alterations in the visual system in the zebrafish mutant fading vision.

Schonthaler, H B; Lampert, J M; von Lintig, J; Schwarz, H; Geisler, R; Neuhauss, S C F

doi:10.5167/uzh-177

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Schonthaler, H. B., Lampert, J. M., von Lintig, J., Schwarz, H., Geisler, R., & Neuhauss, S. C. F. (2005). A mutation in the silver gene leads to defects in melanosome biogenesis and alterations in the visual system in the zebrafish mutant fading vision. Developmental Biology, 284, 421–436. https://doi.org/10.1016/j.ydbio.2005.06.001

Abstract

Forward genetic screens have been instrumental in defining molecular components of visual function. The zebrafish mutant fading vision (fdv) has been identified in such a screen due to defects in vision accompanied by hypopigmentation in the retinal pigment epithelium (RPE) and body melanocytes. The RPE forms the outer most layer of the retina, and its function is essential for vision. In fdv mutant larvae, the outer segments of photoreceptors are strongly reduced in length or absent due to defects in RPE cells. Ultrastructural analys