Publication: Inhibition mediated by group III metabotropic glutamate receptors regulates habenula activity and defensive behaviors
Inhibition mediated by group III metabotropic glutamate receptors regulates habenula activity and defensive behaviors
Date
Date
Date
Citations
Ostenrath, A. M., Faturos, N., Çiftci Çobanoğlu, Y. I., Serneels, B., Jeong, I., Dongel Dayanc, E., Enz, A., Hinrichsen, F., Mutlu, A. K., Bardenhewer, R., Jetti, S. K., Neuhauss, S., Jurisch-Yaksi, N., & Yaksi, E. (2025). Inhibition mediated by group III metabotropic glutamate receptors regulates habenula activity and defensive behaviors. Nature Communications, 16(1), 7187. https://doi.org/10.1038/s41467-025-62115-z
Abstract
Abstract
Abstract
Inhibition plays a key role in brain functions. While typically linked to GABA, inhibition can be induced by glutamate via metabotropic glutamate receptors (mGluRs). Here, we investigated the role of mGluR-mediated inhibition in the habenula, a conserved, glutamatergic brain hub involved in adaptive and defensive behaviors. We found that zebrafish and mice habenula express group III mGluRs. We showed that group III mGluRs regulate membrane potential and calcium activity of zebrafish habenula. Perturbing group III mGluRs increased sens
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
In collections
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Ostenrath, A. M., Faturos, N., Çiftci Çobanoğlu, Y. I., Serneels, B., Jeong, I., Dongel Dayanc, E., Enz, A., Hinrichsen, F., Mutlu, A. K., Bardenhewer, R., Jetti, S. K., Neuhauss, S., Jurisch-Yaksi, N., & Yaksi, E. (2025). Inhibition mediated by group III metabotropic glutamate receptors regulates habenula activity and defensive behaviors. Nature Communications, 16(1), 7187. https://doi.org/10.1038/s41467-025-62115-z
