Publication: Bone marrow-derived mesenchymal stromal cells improve vascular regeneration and reduce leukocyte-endothelium activation in critical ischemic murine skin in a dose-dependent manner
Bone marrow-derived mesenchymal stromal cells improve vascular regeneration and reduce leukocyte-endothelium activation in critical ischemic murine skin in a dose-dependent manner
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Schweizer, R., Kamat, P., Schweizer, D., Dennler, C., Zhang, S., Schnider, J. T., Salemi, S., Giovanoli, P., Eberli, D., Enzmann, V., Erni, D., & Plock, J. A. (2014). Bone marrow-derived mesenchymal stromal cells improve vascular regeneration and reduce leukocyte-endothelium activation in critical ischemic murine skin in a dose-dependent manner. Cytotherapy, 16(10), 1465–1469. https://doi.org/10.1016/j.jcyt.2014.05.008
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BACKGROUND AIMS Stem cells participate in vascular regeneration following critical ischemia. However, their angiogenic and remodeling properties, as well as their role in ischemia-related endothelial leukocyte activation, need to be further elucidated. Herein, we investigated the effect of bone marrow-derived mesenchymal stromal cells (BM-MSCs) in a critically ischemic murine skin flap model.
METHODS Groups received either 1 × 10(5), 5 × 10(5), or 1 × 10(6) BM-MSCs or cell-free conditioned medium (CM). Controls received sodium chlori
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- Schweizer, Riccardo
- Kamat, Pranitha
- Schweizer, Dennis
- Dennler, Cyrill
- Zhang, Shengye
- Schnider, Jonas T
- Salemi, Souzan
- Giovanoli, Pietro
- Eberli, Daniel
- Enzmann, Volker
- Erni, Dominique
- Plock, Jan A
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Schweizer, R., Kamat, P., Schweizer, D., Dennler, C., Zhang, S., Schnider, J. T., Salemi, S., Giovanoli, P., Eberli, D., Enzmann, V., Erni, D., & Plock, J. A. (2014). Bone marrow-derived mesenchymal stromal cells improve vascular regeneration and reduce leukocyte-endothelium activation in critical ischemic murine skin in a dose-dependent manner. Cytotherapy, 16(10), 1465–1469. https://doi.org/10.1016/j.jcyt.2014.05.008